As with the An Dúlamán Irish Maritime Gin, Santa Ana is said to be inspired by the Donegal coastline. Its name comes from La Duquesa Santa Ana, an Andalusian ship which was lost in Philip II’s Spanish Armada conquest to invade England in 1588. The ship was wrecked on 28 September off Loughros Mor, close to
where the An Dúlamán Distillery is located.

All 900 men on board survived, and locals still gather to re-enact the 30km walk undertaken by the crew of the Santa Ana from Rosbeg to Killybegs. The Rioja wine casks used to age the gin have historic connotations as well. The commander of the La Duquesa Santa Ana, Don Alonso de Leyva, who was second in command of the Armada, was from a noble household in the Rioja region of Spain.

The An Dúlamán bottle, inspired by those found along the Donegal coast after ships of the Spanish Armada were wrecked upon the rocks, is also used for Santa Ana, with some marked differences. The wax seal is a deep ruby red and the label is a section from a traditional map, that marks the location of the loss of the La Duquesa Santa Ana.